Sean: That's what families are for--breaking our hearts.
Nikki: And putting them back together.

Sean: The Hutton Academy is not a military school. It's a disciplinary institution.
Christian: And the two plums between my legs are not balls, they're testicles.

Sean: The police found a condom a the crime scene with Christian's DNA.
Quentin: So? The police planted it, that happens all the time.
Sean: DNA doesn't lie.
Quentin: Ask O.J. He'll tell you otherwise.

Sean: There's a reason I'm a plastic surgeon. If something's ugly, I fix it. What's imperfect, I make perfect, wipe away the mess, make it all nice. I couldn't do what these guys do. Life and death. Losing more than you save and moving on to the next, just one after the other.

Sean: They should just be honest and rename the show "Shit".
Christian: Shit.

Sean: To our profession. The only field of medicine dedicated to both the fixing of what isn't broken and rebuilding of the unrepairable.

Sean: Wake up, Christian! Our coddling and laissez-faire attitude led him to getting pissed on by a bunch of transexuals!

Sean: We don't need you for this surgery, Quentin. Why don't you just go home?
Christian: Or why don't you head down to the docks? I hear there's a whole bunch of sailors just arrived with three-day passes.

Sean: What's the big deal? What part of you being or having an asshole could shock me?

Sean: Where is Christian?
Liz: I'm sure his spirits are here, but his body is still in the tanning booth.

Sean: Why haven't you asked me about Monica? What I did, why I did it.
Julia: I know why you did it. The same reason that I had an affair with Marlowe.
Sean: I want to talk about it.
Julia: I already know all the answers. So do you.

Sean: You're a remarkable person, Jules. Every time I look at you in there, so capable, strong, not afraid of any of it. You'd have made a much better doctor than I am. I always thought I was the one who could handle anything. Who wasn't afraid to get his hands dirty, could deal with all the shit that's just part of life. I never wanted to know about Matt because I couldn't live with the truth. I never asked about you and Christian. I couldn't deal with all the questions I'd have to ask about us.

Sean: You've seen how he treats women: like they're sub-human.
Liz: Hasn't stopped me from working with Christian.
[Edit]
Christian: Don't take this the wrong way. But you're a better man than I am.
Liz: Damn straight.
Season 2

Sean: You´re the one who inspired me to be a surgeon. I wanted to be you.
Dr. Grayson: You´re gonna be me, Sean. You´re in my path. You´re a success now. Forty is when it starts. The dutiful wife gets tired of your hours and your lack of emotional intelligence. She´ll stay around for another five years if you´re lucky. Mine left when I was 50, but she´ll leave. When Father´s Day comes around, and Christmas, and Thanksgiving, and you sit alone with your diplomas, and the thoughts of all these people whose lives you´ve saved except your own.

Sophia: Have you always been a lesbian, Liz?
Liz: I slept with a man once in college. He had long hair and when I closed my eyes, and felt it sweeping across my face, I pretended it was Joni Mitchell.