[Sheldon is trying Howard's driving simulator - with disastrous results]
Leonard: How did you manage to get on the second floor of the Glendale Galleria?
Sheldon: I don't know, I was on the Pasadena Freeway, missed my exit, flew off the overpass and...one thing led to another.
[Screeching tires are heard from the simulator, followed by a crash and barking and meowing]
Leonard: Awwwwww, the pet store��
Sheldon: Remind me to compliment Wolowitz on the software, it's amazingly detailed.

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