Desmond: [to Jack] But the first piece of land I saw wasn't Fiji was it, no... No it was here, this... this island. And you know why?
[Jack shakes his head]
Desmond: Because this, is it. This is all there is left. This ocean, and this place here, we are stuck in a bloody snowglobe!

Desmond: I love you, Penny. I've always loved you. I'm so sorry. I love you.
Penelope: I love you too.
Desmond: I don't know where I am but,
Penelope: I'll find you, Des,
Desmond: I promise,
Penelope: no matter what-
Desmond: I'll come back to you.
Penelope: I won't give up.
Desmond: I promise.
Penelope: I promise.
Desmond, Penelope: I love you.

Desmond: I'm sorry, brother, but this time - this time you have to die

Desmond: Lower your gun, or I'll blow his damn head off, brother!
Jack: You.

Desmond: On that day, those numbers turned to hieroglyphics, and this whole place just starting shakin', and that screen- that screen filled up with 'SYSTEM FAILURE', see, here, 'SYSTEM FAILURE, SYSTEM FAILURE', September 22nd, 2004, the day your plane crashed, it's real, it's all bloody real now PUSH THE DAMN BUTTON!

Desmond: We're here.
Charlie: I want you to give this to Claire for me.
Desmond: What is it?
Charlie: It's the five best moments of my sorry excuse for a life, my greatest hits. You know, memories are all I've got.

Desmond: What did one snowman say to the other snowman?
Locke: I don't know what you're talking about...
Desmond: Get rid of the knife. You're not HIM!

Dharma Worker: There's an open chamber about twenty meters in behind the rock. There's something in there. And the only way to get it is to lay charges here and here, blast through it-
Pierre Chang (From Orientation videos): Under no circumstances. This station is being built here because it's proximity to what we believe to be an almost limitless energy and that energy, once we can harness it correctly, it's going to allow us to manipulate time.
Worker: Right... Okay, so what? We're gonna go back and kill Hitler?
Pierre Chang: Don't be absurd. There are rules. Rules that can't be broken.
Worker: So what do you want me to do?
Pierre Chang: You're gonna do nothing. If you drill even one centimeter further, you risk releasing that energy. If that would've happened... God help us all.
(Jack stares at Locke's body, Ben comes up with a stretcher)

Diane: I made my bed Katherine.
Kate: Your bed's gone ma.

Dr. Brooks: Dave isn't your friend, Hugo. Because Dave doesn't exist.

Edmund Burke: [on mobile phone] Because you're insufferable. And you're mean. Well, you asked me for the truth, Mom.

Eko: Yes, I am ready. I ask for no forgiveness, Father, for I have not sinned. I have only done what I needed to do to survive. A small boy once asked me if I was a bad man. If I could answer him now, I would tell him that when I was a young boy, I killed a man to save my brother's life. I am not sorry for this. I am proud of this. I did not ask for the life I was given, but it was given nonetheless, and with it, I did my best.
Yemi: You speak to me as if I was your brother.

Eko: Do you know what baptism is?
Claire: It's what gets you into heaven.
Eko: It is said that when John the Baptist baptized Jesus the skies opened up and a dove flew down from the sky. This told John something -- that he had cleansed this man of all his sins. That he had freed him. Heaven came much later.

Eko: Don't mistake coincidence for fate.

Eko: How many of the statues do you have? The Virgin Mary statues?
Yemi: I have 300.
Eko: I will take all of them. I guess we are both sinners now.
Yemi: Perhaps we are. But God will forgive me Eko.